解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:OBJECTIVE:The gut microbiota, which is considered a causal factor in metabolic diseases as shown best in animals, is under the dual influence of the host genome and nutritional environment. This study investigated whether the gut microbiota per se, aside from changes in genetic background and diet, could sign different...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2011-301012
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND:Recent profile studies of microRNA (miRNA) expression have documented a deregulation of miRNA (miR-124) in hepatocellular carcinoma (HCC). OBJECTIVE:To determine the status of miR-124 expression and its underlying mechanisms in the pathogenesis of HCC. METHODS:The expression levels of miR-124 were first ex...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2011.239145
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND AND AIMS:Gastrokine 1 (GKN1) is a stomach-specific protein that is normally expressed in gastric mucosa but not in primary tumours and cell lines. Based on this evidence, it was presumed that GKN1 might play a role in gastric cancer development; however, its function and molecular mechanism are not clear. A ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2010.230623
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVES:To compare performance measures across all three rounds of the English bowel cancer screening faecal occult blood test pilot and their relation to social deprivation and ethnicity. METHODS:In each round in three primary care trusts, data for a restricted population of over 48,500 aged 60-69 years were analy...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2010.236430
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome and is associated with cardiovascular risk. The aim of this study was to determine the role of fatty liver in predicting coronary artery disease and clinical outcomes in patients undergoing coronary angiogram. METHOD...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2011.242016
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND AND AIM:Hepatic stellate cells (HSCs) are key participants in liver fibrosis development. 1,25(OH)(2)D(3), the active form of vitamin D, has antiproliferative properties and antifibrotic potential, as well as a role in extracellular matrix and matrix metalloproteinase (MMP) regulation in renal and lung fibro...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2010.234666
更新日期:2011-12-01 00:00:00
abstract:OBJECTIVE:Postpolypectomy surveillance guidelines for colorectal cancer introduced the concept of 'risk stratification'; however, few studies have been conducted for validation of its usefulness. The aim of this study was to assess the 5-year incidence of advanced neoplasia recurrence based on the risk stratification s...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2010.232876
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND AND AIMS:Inflammatory bowel disease (IBD) is initiated and perpetuated by a dysregulated immune response to unknown environmental antigens such as luminal bacteria in genetically susceptible hosts. SR-PSOX/CXCL16, a scavenger receptor that binds phosphatidylserine and oxidised lipoprotein, has both phagocyti...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2010.221879
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND AND AIMS:CD8 T cells are central to the control of hepatitis C virus (HCV) although the key features of a successful CD8 T cell response remain to be defined. In a cohort of Irish women infected by a single source, a strong association between viral clearance and the human lecucocyte (HLA)-A*03 allele has be...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2010.228403
更新日期:2011-11-01 00:00:00
abstract::Glycosylation is a key modification of proteins and lipids and is involved in most intermolecular and intercellular interactions. The gastrointestinal mucus gel is continuous and can be divided into two layers: a secreted loosely associated layer and a layer firmly attached to the mucosa. In addition, the membrane-bou...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gut.2010.212704
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND AND AIMS:The incidence of oesophageal adenocarcinoma (OAC) has been increasing rapidly with a dismal survival rate of less than 20%. Understanding the genomic aberrations and biology of this cancer may enhance disease interventions. This study aimed to use genome-wide genomic and expression data to enhance t...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2010.234179
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND AND AIMS:Bariatric surgery is increasingly performed worldwide to treat morbid obesity and is also known as metabolic surgery to reflect its beneficial metabolic effects especially with respect to improvement in type 2 diabetes. Understanding surgical weight loss mechanisms and metabolic modulation is requir...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2010.234708
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND AND AIMS:The effectiveness of surveillance for hepatocellular carcinoma (HCC) in the USA is largely unknown. The objective of this study was to evaluate the effectiveness of HCC surveillance in a national Veterans Administration (VA) practice setting, using the national VA hepatitis C virus (HCV) Clinical Ca...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2010.230508
更新日期:2011-07-01 00:00:00
abstract:BACKGROUND AND AIMS:Teduglutide, a GLP-2 analogue, may restore intestinal structural and functional integrity by promoting repair and growth of the mucosa and reducing gastric emptying and secretion, thereby increasing fluid and nutrient absorption in patients with short bowel syndrome (SBS). This 24-week placebo-contr...
journal_title:Gut
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/gut.2010.218271
更新日期:2011-07-01 00:00:00
abstract:BACKGROUND AND AIMS:Coeliac disease (CD) is triggered by an abnormal reaction to gluten. Peptides resulting from partially digested gluten of wheat, barley or rye cause inflammation of the small intestinal mucosa. Previous contradictory studies suggest that oats may trigger the abnormal immunological response in patien...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2010.225268
更新日期:2011-07-01 00:00:00
abstract:BACKGROUND AND AIM:Colorectal cancer (CRC) is a multifactorial disease with both environmental and genetic factors contributing to its development. The incidence of CRC is increasing year by year in Japan. Patients with CRC in advanced stages have a poor prognosis, but detection of CRC at earlier stages can improve cli...
journal_title:Gut
pub_type: 杂志文章,meta分析
doi:10.1136/gut.2010.215947
更新日期:2011-06-01 00:00:00
abstract:OBJECTIVE:Early detection and early treatment are of vital importance to the successful treatment of various cancers. The development of a novel screening method that is as economical and non-invasive as the faecal occult blood test (FOBT) for early detection of colorectal cancer (CRC) is needed. A study was undertaken...
journal_title:Gut
pub_type: 杂志文章,随机对照试验
doi:10.1136/gut.2010.218305
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND:Acute pancreatitis is among the few inflammatory diseases for which no specific pharmacological treatment is available. It has previously been shown that bile acids alter pancreatic ductal secretion and these effects are probably involved in the pathogenesis of bile-induced pancreatitis. OBJECTIVE:To unders...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2010.214213
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVES:Recent studies using the lactulose hydrogen breath test (LHBT) suggest most patients with irritable bowel syndrome (IBS) have small intestinal bacterial overgrowth (SIBO). However, the validity of the LHBT has been questioned, particularly as this test could reflect changes in oro-caecal transit. Therefore, ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2009.205476
更新日期:2011-03-01 00:00:00
abstract:BACKGROUND:The identification of gastric superficial cancerous lesions based on conventional white-light endoscopy (WLE) is challenging, and histological analysis remains the 'gold standard' for the final diagnosis. Confocal laser endomicroscopy (CLE) can provide in vivo histological observation without the need for bi...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2010.223586
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVE:Hepatocellular adenomas (HCAs) classically develop in women who are taking oral contraceptives and have a risk of malignant transformation into hepatocellular carcinoma (HCC). HCA with malignant transformation is, however, an ill-defined entity thought to be an anecdotic pathway to HCC. The objective of this ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2010.222109
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:The indications for intestinal transplantation (ITx) are still debated. Knowing survival rates and causes of death on home parenteral nutrition (HPN) will improve decisions. METHODS:A prospective 5-year study compared 389 non-candidates (no indication, no contraindication) and 156 candidates (indication, no...
journal_title:Gut
pub_type: 杂志文章,多中心研究
doi:10.1136/gut.2010.223255
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND AND AIMS:Crohn's disease (CD) ileal lesions are colonised by pathogenic adherent-invasive Escherichia coli (AIEC) producing outer membrane vesicles (OMVs) that contribute to the bacterial invasion process. In addition, increased expression of endoplasmic reticulum (ER)-localised stress response proteins, due...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2010.207456
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND:Oligodeoxynucleotides (ODNs) containing unmethylated cytosine-guanosine (CpG) sequence motifs constitute the immunostimulatory components of bacterial DNA which potently activate innate immunity. Administration of CpG-ODNs before the onset of experimental colitis prevents intestinal inflammation by induction...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2009.193177
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND:There is no information about the frequency of liver dysfunction in patients with inflammatory bowel disease (IBD) treated with immunosuppressants and infected with hepatitis B (HBV) and/or C virus (HCV). AIM:To assess the influence of immunosuppressants on the course of HBV and HCV infection in IBD. METHO...
journal_title:Gut
pub_type: 杂志文章,多中心研究
doi:10.1136/gut.2010.208413
更新日期:2010-10-01 00:00:00
abstract::Hepatitis C virus (HCV) is a human pathogen responsible for acute and chronic liver disease, infecting an estimated 130-170 million persons worldwide. An intriguing feature of HCV infection is its peculiar relationship with lipids: (1) HCV virions circulate in serum bound to lipoproteins; (2) lipids have been shown to...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gut.2009.192732
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND AND AIMS:Helicobacter pylori (H pylori) infection is a major risk factor in the development of distal gastric adenocarcinoma. Development of the invasive phenotype is associated with the phenomenon of epithelial:mesenchymal transition (EMT). Soluble heparin-binding epidermal growth factor (HB-EGF) has been i...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2009.199794
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:Vascular endothelial growth factor (VEGF) is a therapeutic target in gastrointestinal cancer (GiC). However, its in vivo visualisation could not be achieved to date with endoscopic techniques. Confocal laser endomicroscopy (CLE) is a novel imaging technique for gastrointestinal endoscopy providing in vivo mi...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2009.202986
更新日期:2010-08-01 00:00:00
abstract:OBJECTIVE:Magnetic resonance imaging (MRI) enables accurate assessment of inflammatory bowel diseases (IBD), but its main limitation is the need for bowel preparation. Diffusion-weighted imaging is feasible in Crohn's disease. We evaluated the accuracy of MRI in combination with diffusion-weighted imaging (DWI-MRI) wit...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2009.197665
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND/AIMS:To investigate the prognostic values of putative hepatic stem/progenitor cell (HSC/HPC) biomarkers in patients with hepatocellular carcinoma (HCC). METHODS:Fourteen biomarkers related to HSCs/HPCs or tumour angiogenesis were assessed by qRT-PCR and then validated by tissue microarrays (TMAs) in three i...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2008.176271
更新日期:2010-07-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to compare azathioprine versus mesalazine tablets for the prevention of clinical recurrence in patients with postoperative Crohn's disease (CD) with moderate or severe endoscopic recurrence. METHODS:This was a 1 year, double-blind, double-dummy, randomised study which took place in 2...
journal_title:Gut
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/gut.2009.194159
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:The efficacy of a levofloxacin-based regimen as the first-line treatment and a clarithromycin-based regimen as the second-line treatment for Helicobacter pylori infection remains unknown. The aim of this study was to assess the eradication rates of these two regimens using different administration sequences....
journal_title:Gut
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/gut.2009.198309
更新日期:2010-05-01 00:00:00
abstract:OBJECTIVE:The death rate of mature hepatocytes is chronically increased in various liver diseases, triggering responses that prevent liver atrophy, but often cause fibrosis. Mice with targeted disruption of inhibitor kappa B kinase (Ikk) in hepatocytes (HEP mice) provide a model to investigate this process because inhi...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2009.204354
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND:Human growth factors are potential therapeutic agents for various inflammatory disorders affecting the gastrointestinal tract. However, they are unstable when administered orally and systemic administration requires high doses increasing the risk of unwanted side effects. Live microorganism-based delivery sy...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2008.176131
更新日期:2010-04-01 00:00:00
abstract:BACKGROUND:Although evidence points to a role for histamine and serotonin in visceral hypersensitivity, activation of calcium channels such as transient receptor potential vanilloid 4 (TRPV4) also causes visceral hypersensitivity. We hypothesised that TRPV4 is important for the generation of hypersensitivity, mediating...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2009.192567
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVE:Chronic pancreatitis is a progressive inflammatory disorder of the pancreas characterised by permanent destruction of acinar cells. Mutations in the chymotrypsinogen C (CTRC) gene have been linked to the development of chronic pancreatitis. The aim of the present study was to explore whether CTRC mutants indu...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2009.198903
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND AND AIMS:Interleukin-6 (IL-6) is a well-recognised mediator of liver disease and regeneration. However, the in vivo effects of IL-6 on enterocytes and the intestinal tract have not been elucidated. We sought to determine the in vivo effects of IL-6 on enterocytes. METHODS:Murine models of increased or absen...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2008.151175
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND AND AIMS:Hepatocellular carcinoma (HCC) frequently results from synergism between chemical and infectious liver carcinogens. Worldwide, the highest incidence of HCC is in regions endemic for the foodborne contaminant aflatoxin B1 (AFB1) and hepatitis B virus (HBV) infection. Recently, gut microbes have been ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2009.183749
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVE:Eosinophilic oesophagitis (EoO) is a clinicopathological condition defined by proton pump inhibitor-refractory oesophageal symptoms combined with oesophageal eosinophilia. The pharmacodynamic effect of mepolizumab (a humanised anti-interleukin-5 monoclonal antibody) in EoO was evaluated. METHODS:Eleven adult...
journal_title:Gut
pub_type: 杂志文章,随机对照试验
doi:10.1136/gut.2009.178558
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVE:To establish an appropriate steroid treatment regimen for autoimmune pancreatitis (AIP). METHODS:A retrospective survey of AIP treatment was conducted in 17 centres in Japan. The main outcome measures were rate of remission and relapse. RESULTS:Of 563 patients with AIP, 459 (82%) received steroid treatment....
journal_title:Gut
pub_type: 杂志文章,多中心研究
doi:10.1136/gut.2008.172908
更新日期:2009-11-01 00:00:00